Tottenham and the Red Devils are still in the competition.
Man United and Spurs have learned their European fates after the draw for the Europa League was made on Friday.
Both clubs automatically qualified for the round of 16, avoiding a tough play-off round.
Unlike their league form, both clubs saw relative success in the league phase, with United finishing third and Spurs fourth respectively.
Now, the draw has been made and a trip to Spain will be on the cards for United as they play Real Sociedad.
Meanwhile, Spurs drew Dutch team AZ Alkmaar. Republic of Ireland striker Troy Parrott plays for Alkmaar and will face his former team Tottenham in the next round.
Rangers were given what could be the toughest tie for the UK teams, as they face José Mourinho’s Fenerbahçe.
The full draw is as follows:
Viktoria Plzen vs Lazio
Bobo/Glimt vs Olympiacos
Ajax vs Frankfurt
AZ Alkmaar vs Tottenham
Real Sociedad vs Man Utd
FCSB vs Lyon
Fenerbahce vs Rangers
Roma vs Atletic Club