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Published 13:46 10 Nov 2016 GMT
Updated 22:08 10 Nov 2016 GMT
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Up front, Cian Healy is joined by Sean Cronin and Finlay Bealham. Holland is in for his first Ireland start as is Dillane, who has thus far been an impact sub.
The back row has Peter O'Mahony, the captain, in with Sean O'Brien and O'Donoghue, a new face at No.8. The former Ireland U20 captain has been in fine form for Munster this season. Despite that, many had predicted O'Donoghue would only be on the bench.
The five newbies on the bench are James Tracy, John Ryan, Dan Leavy, Luke McGrath and Niyi Adeolokun. There is no room in the squad for Iain Henderson, who injured his shoulder on Ulster duty last month.
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