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Published 13:36 16 Mar 2016 GMT
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Joe Schmidt may use the game as an opportunity to give Sean Cronin his first ever Six Nations start. Given the fact that Cronin has 50 caps to his name, that is a remarkable anomaly.
Should Best train fully on Thursday morning, Schmidt will name an unchanged XV from the one that dismantled Italy 58-15.
Once again, that means Simon Zebo at fullback, Jack McGrath at loosehead, Ultan Dillane on the bench and no spot for Stuart McCloskey.
Schmidt's only other decisions to make are on the bench. Cian Healy is set to replace Finlay Bealham but Kieran Marmion looked to have done enough to stave off the returning Eoin Reddan.
IRELAND'S EXPECTED TEAM
15. Simon Zebo
14. Andrew Trimble
13. Jared Payne
12. Robbie Henshaw
11. Keith Earls
10. Johnny Sexton
9. Conor Murray
1. Jack McGrath
2. Rory Best
3. Mike Ross
4. Donnacha Ryan
5. Devin Toner
6. CJ Stander
7. Josh van der Flier
8. Jamie Heaslip
Replacements: Cronin, C Healy, White, Dillane, Ruddock, Marmion, Madigan, McFadden.

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