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Published 11:21 3 Jan 2017 GMT
Updated 12:11 3 Jan 2017 GMT
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Sunderland, Leicester, Stoke and Watford have lost three players each to the tournament.
The clubs unaffected by the competition are Burnley, Chelsea, Manchester City, Middlesbrough, Swansea, Tottenham and West Brom. Liverpool defender Joel Matip will be available for selection, after refusing to join-up with Cameroon's squad.
Here's the full list of Premier League players who have departed for the Africa Cup of Nations:
Arsenal: Ismael Bennacer (Algeria), Mohamed Elneny (Egypt). Bournemouth: Max Gradel (Ivory Coast). Crystal Palace: Bakary Sako (Mali), Wilfried Zaha (Ivory Coast). Everton: Idrissa Gueye (Senegal). Hull City: Ahmed Elmohamady (Egypt), Dieumerci Mbokani (DR Congo). Leicester City: Daniel Amartey (Ghana), Riyad Mahrez (Algeria), Islam Slimani (Algeria). Liverpool: Sadio Mane (Senegal). Manchester United: Eric Bailly (Ivory Coast). Southampton: Sofiane Boufal (Morocco). Stoke City: Wilfried Bony (Ivory Coast), Mame Biram Diouf (Senegal), Ramadan Sobhi (Egypt). Sunderland: Wahbi Khazri (Tunisia), Lamine Kone (Ivory Coast), Didier N'dong (Gabon). Watford: Nordin Amrabat (Morocco), Brice Dja Djedje (Ivory Coast), Adlene Guedioura (Algeria). West Ham: Andre Ayew (Ghana), Cheikou Kouyate (Senegal).
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