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Published 13:22 6 Oct 2019 BST
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Out of the players injured or, in Enda Stevens' case, suspended, four would have been expected to slot into Mick McCarthy's starting XI.
That means several changes will need to be implemented with the Irish defence set for a dramatic makeover. Shane Duffy is not yet ruled out but Richard Keogh's season is over after he was involved in a car crash while Stevens misses the Georgia game after picking up three yellow cards.
John Egan and Kevin Long look set to partner each other in the centre of defence if Duffy misses one or both of the upcoming fixtures. With Stevens out, we are drafting in Matt Doherty to play left back while Seamus Coleman starts at right back.
Conor Hourihane and Jeff Hendrick are in goalscoring form and slot into the Irish midfield with James McClean and Glenn Whelan joining them. Callum Robinson will be tasked with holding down the right wing slot while getting up in support of the lone frontman when possible.
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Up front, if McGoldrick does not recover in time, Aaron Connolly goes straight in for his senior debut. Even if McGoldrick is passed fit, it is sorely tempting to go with Under-21 star Connolly from the off.
The 19-year-old scored his second and third goals of the season against last season's Champions League finalists, Spurs on Saturday and was singled out for praise - "He was magnificent" - by Alan Shearer on Match of the Day.
If it feels like a dice roll, McCarthy can look back to March 1998 when he gave a 17-year-old Robbie Keane his debut away to Czech Republic. That didn't work out too badly.
1. Darren Randolph 2. Seamus Coleman 3. Matt Doherty 4. John Egan 5. Kevin Long (*Shane Duffy if fit) 6. Glenn Whelan 7. Conor Hourihane 8. Jeff Hendrick 10. Callum Robinson 11. James McClean 9. Aaron Connolly
That leaves the likes of Alan Browne, Sean Maguire, Alan Judge, Jack Byrne and Scott Hogan in reserve as McCarthy will definitely need quality coming from the bench in the final 20 to 30 minutes.

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