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Published 15:42 3 Oct 2015 BST
Updated 07:19 19 Feb 2018 GMT
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Schmidt has dealt well with two injury snags to select a gutsy XV.
By all accounts, stats, form guides and gut feelings, Ireland should have too much for the Azzurri. World Cups are not always that predictable, however.
Here is the current State of the Nation...
Ireland have racked up 94 points and 13 tries in their opening two games, albeit against the Canadians and Romania.
A slew of Irish players are in form, most notably Simon Zebo, Keith Earls, Dave Kearney and just about any back that has caught a whiff of game-time.
Kearney would have, no doubt, featured at fullback had the game been a must-win. Schmidt says the Leinster man will be fit to face France, if called upon, on Sunday week.
As it is, and with Zebo in flying form, Schmidt can afford to rest him up for the crunch game against France.
The Munster man has won the trust of his coach after injury denied him a chance to play under the Kiwi for his first two years.
Earls is showing all the sensational form that won him a spot on the 2009 Lions Tour and that saw him bag five World Cup tries in 2011.
His pace and ability to step his man, or men, is fantastic and he is the one back that can provide line breaks from midfield. His defence has improved massively but he is still capable of a major gaffe every couple of games.
Schmidt will hope that flaw will be buried, once and for all, in the Olympic Stadium.
Priority number one is getting over that finishing line with a point to spare and as many uninjured men as possible.
Anything after that is a bonus, but it would be great to see this excellent start maintained with some more sublime tries, punishing mauls and crumpling Italian scrums.
"We felt that Keith Earls, in pre-season, had shown a real sharpness at outside centre. [Playing Earls 13] allows us to have Dave Kearney and Tommy Bowe on the pitch at the same time."- Joe Schmidt on his revamped backline
"Murray is very physical and controls the team’s tactics fantastically well and has a good kick. He’s a complete player and possibly the best scrum-half in the world."- Italian scrum-half Edoardo Gori on our Conor
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